In vitro Antileishmanial Activity of Pleumeria pudica Leaf Extracts on Leishmania donovani Promastigotes
نویسندگان
چکیده
The objective of the present study was to evaluate in vitro antileishmanial activity of leaves form Plumeria pudica Jacq. (Apocynaceae). In the present study, the in vitro antileishmanial activity of petroleum ether, chloroform and methanol extracts from P. pudica leaf was evaluated against Leishmania donovani (strain AG 83) promastigotes by in vitro promastigote cell toxicity assay by using MTT [3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide]. Here, all extracts markedly inhibited the growth of L. donovani promastigotes in vitro in a concentration dependent manner. The methanol extract was the most active followed by chloroform and petroleum ether extracts. Therefore, from the present study it can be inferred that P. pudica leaf exhibited remarkable antileishmanial activity against Leishmania donovani promastigotes in vitro.
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